forever seeking interesting answers to complicated questions.
This question led me to pursue a graduate degree in Biotechnology and Bioinformatics.
I explored this question during my PhD and my stint as a Postdoctoral Fellow.
Currently exploring the immense possibilities of data science and machine learning.
Developed a machine learning pipeline to predict whether an individual will develop inflammatory bowel disease (IBD) solely using genomic data
Uncovered the complex dynamics regulating natural transformation, type six secretion and chitin metabolism critical for evolution of a human pathogen Vibrio cholerae.
1. Barrasso K, Watve S, Simpson C, Geyman L, van Kessel J, Ng WL (2020); Dual-function quorum-sensing systems in bacterial pathogens and symbionts. PloS Pathogens. https://doi.org/10.1371/journal.ppat.1008934
2. Watve S, Barrasso K, Jung S, Davis K, Hawver L, Khataokar A, Palaganas R, Neiditch M, Perez L, Ng WL (2020); Parallel quorum sensing system in Vibrio cholerae prevents signal interference inside the host. PLoS Pathogens. https://doi.org/10.1371/journal.ppat.1008313
3. Crisan C, Chande A, Williams K, Raghuram V, Rishishwar L, Steinbach G; Watve S, Yunker P, Jordan I K, Hammer B (2019); Analysis of Vibrio cholerae genomes identifies new Type VI Secretion System gene clusters; Genome Biology.
https://doi.org/10.1186/s13059-019-1765-5
4. Thomas J, Watve S, Ratcliff W, Hammer B (2017); Horizontal Gene Transfer of Functional Type VI Killing Genes by Natural Transformation. mBio, 8(4), e00654–17. http://doi.org/10.1128/mBio.00654-17
5. Austin C, Caro D, Sankar S, Penniman W, Perdomo J, Hu L, Patel S, Gu X, Watve S, Hammer B, Forest C (2017); Porous monolith microfluidics for bacterial cell-to-cell communication assays. Biomicrofluidics. https://doi.org/10.1063/1.4995597
6. Watve S, Chande A, Rishishwar L, Mariño-Ramírez L, King Jordan I, and Hammer B (2016); Whole-genome sequences of 26 Vibrio cholerae isolates. Genome Announcements 4, no. 6 : e01396-16. https://doi.org/10.1128/genomeA.01396-16
7. Watve S, Thomas J, Hammer B (2015); CytR is a global regulator that positively regulates competence, type VI secretion, and chitinase expression in Vibrio cholerae. PLoS ONE 10(9): e0138834. https://doi.org/10.1371/journal.pone.0138834
8. Watve S, Bernardy EE, Hammer BK (2014); Vibrio cholerae: Measuring natural transformation frequency. Current Protocols Microbiol. 35:6A.4.1-6A.4.12. https://doi.org/10.1002/9780471729259.mc06a04s35
9. Watve M, Watve S, Belsare P, Lele U, Bari S, and Karande S; Caloric restriction causes symmetric cell division and delays aging in Escherichia coli. Nat Prec (2008); https://doi.org/10.1038/npre.2008.2071.1
